教师简介：
姓 名：陈冬冬
性 别：女
政治面貌：群众
职 称：讲师
职 务：无
研究方向： 兽医微生物及免疫
联系电话：15660005050
电子邮箱：kristen1107@163.com
二、受教育经历
2018-09至 2022-07,中国疾病预防控制中心,免疫学,博士
2015-09至 2018-06,中国农业科学院,兽医,硕士
2011-09至 2015-07,河南农业大学,药物制剂,学士
三、研究工作经历
2022-11至 今,福建农林大学,bat365在线官网（蜂学学院）,讲师
四、科研项目
1.国家自然科学基金委员会,面上项目, 31772763, ATG9-ATG16L1囊泡融合在口蹄疫病毒内体运输过程 中的效应机制研究, 2018-01-01至 2021-12-31, 59万元,结题,参与
2.国家自然科学基金委员会，面上项目，32372998，DNA损伤应答在流感病毒与宿主互作过程中的作用及其机制，2024-01-01至2027-12-31，参与
五、承担课程
兽医综合实验技术，动物行为与福利，预防兽医实验一
六、科研成果
1. α-突触核蛋白在朊病毒病中的变化研究, 2021年青年学术交流会, 中国疾病预防控制中心传染病预防控制所, 2021-12-23至2021-12-23 (会议报告)
2.一种O型口蹄疫病毒突变株及其制备方法和应用, 2020-07-03, 中国,CN201811406871.8 (专利，共同发明人)
七、代表性论文与著作
以第一作者发表SCI论文5篇，中文核心论文3篇，共同作者发表SCI论文7篇。
1.Title: Aberrant SENP1-SUMO-Sirt3 Signaling Causes the Disturbances of Mitochondrial Deacetylation and Oxidative Phosphorylation in Prion-Infected Animal and Cell Models. ACS Chem Neurosci. 2023 May 3;14(9):1610-1621. doi: 10.1021/acschemneuro.2c00786. Epub 2023 Apr 24. PMID: 37092685.
Authors: Chen DD, Shi Q, Liu X, Liang DL, Wu YZ, Fan Q, Xiao K, Chen C, Dong XP.
2.Title: Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson's Disease.
Authors:Chen DD, Jiao L, Huang Y, Kang X, Gao LP, Chen C, Shi Q, Dong XP. Frontiers in aging neurosci.2022 Jul 1;14:898516. doi: 10.3389/fnagi.2022.898516. PMID: 35847665; PMCID: PMC9283982.
3.Title: Accumulation of Prion and Abnormal Prion Protein Induces Hyperphosphorylation of α-Synuclein in the Brain Tissues from Prion Diseases and in the Cultured Cells.
Authors: Chen DD, Gao LP, Wu YZ, Chen J, Hu C, Xiao K, Chen C, Shi Q, Dong XP. ACS Chem Neurosci. 2021 Oct 20;12(20):3838-3854. doi: 10.1021/ acschemneuro.1c00240. Epub 2021 Oct 1. PMID: 34595918.
4.Title: Global Profiles of Acetylated Proteins in Brains of Scrapie Agents 139A- and ME7-infected Mice Collected at Mid-early, Mid-late, and Terminal Stages.
Authors: Shi Q1, Chen DD1, Adalati M, Xiao K, Gao LP, Yang XH, Wu YZ, Chen C, Dong XP. Biomed Environ Sci.2022 Aug 20;35(8):722-734. doi: 10.3967/bes2022.094. PMID: 36127784.
5.Title: Protein amplification technology: New advances in human prion disease diagnosis.
Authors: WuJX1, Chen DD1, Shi Qi, Dong XP. Biosafety and Health. Volume 3, Issue 6,2021,Pages 325-332,ISSN 2590-0536,https://doi.org/10.1016/j.bsheal.2021.09.003.
6.Title:VP3 G–H环中氨基酸突变对O型口蹄疫病毒生物学特性的影响Authors:陈冬冬,白兴文,宫晓华,包慧芳,李平花,李冬,付元芳,白启峰,袁红,孙普,马雪青,曹轶梅,陈应理,卢曾军,刘在新.[J].微生物学报,2019,59(07):1285-1294.DOI:10.13343/j.cnki.wsxb.20180381.
7.Title:蛋白质体外扩增技术在神经退行性疾病诊断中的应用Authors:陈冬冬,石琦,董小平.[J].疾病监测,2022,37(02):180-184.
8.Title:朊病毒感染对细胞中三羧酸循环关键催化酶的影响研究Authors:陈冬冬,高利萍,刘楚眸,刘欣,肖康,石琦,董小平.[J].病毒学报,2022,38(03):666-674.DOI:10.13242/j.cnki.bingduxuebao.004
9.Title: Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents.
Authors: Hu C, Chen C, Xia Y, Chen J, Yang W, Wang L, Chen DD, Wu YZ, Fan Q, Jia XX, Xiao K, Shi Q, Chen ZB, Dong XP. Front Cell Dev Biol. 2022 May 12;10:844378. doi: 10.3389/fcell.2022.844378. PMID: 35646890; PMCID: PMC9133610.
10. Title: Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease.
Authors: Shi Q, Chen C, Xiao K, Zhou W, Gao LP, Chen DD, Wu YZ, Wang Y, Hu C, Gao C, Dong XP. Neurosci Bull. 2021 Nov;37(11):1570-1582. doi: 10.1007/s12264-021-00764-y. Epub 2021 Sep 6. PMID: 34487324; PMCID: PMC8566684.
11.Title: Generation and characterization of two strains of transgene mice expressing chimeric MiniSOG-MusPrP.
Authors: Gao LP, Wu YZ, Xiao K, Yang XH, Chen DD, Shi Q, Dong XP. J Neurosci Methods. 2020 Jul 15;341:108764. doi: 10.1016/j.jneumeth.2020.108764. Epub 2020 May 13. PMID: 32416277.
12.Title: Enhanced Mitophagy Activity in Prion-Infected Cultured Cells and Prion-Infected Experimental Mice via a Pink1/Parkin-Dependent Mitophagy Pathway. Authors: Gao LP, Xiao K, Wu YZ, Chen DD, Yang XH, Shi Q, Dong XP.ACS Chem Neurosci. 2020 Mar 4;11(5):814-829. doi: 10.1021/acschemneuro.0c00039. Epub 2020 Feb 25. PMID: 32049477.
13. Title: Preparation of PrP-specific Polyclonal Antibody via Immunization of PRNP-knockout Mice with Recombinant Human PrP Protein.
Authors: Yang XH, Wu YZ, Xiao K, Gao LP, Chen DD, Dong XP, Shi Q. Biomed Environ Sci. 2020 Jul 20;33(7):493-501. doi: 10.3967/bes2020.066. PMID: 32807268. 14.Title: Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.
Authors: Yang XH, Xiao K, Wu Y, Gao LP, Chen DD, Dong XP, Shi Q. Prion. 2020 Dec;14(1):20-23. doi: 10.1080/19336896.2019.1704496. PMID: 31880206; PMCID: PMC6959281.
15. Title: Engineering Responses to Amino Acid Substitutions in the VP0- and VP3-Coding Regions of PanAsia-1 Strains of Foot-and-Mouth Disease Virus Serotype O.
Authors: Bai XW, Bao HF, Li PH, Ma XQ, Sun P, Bai QF, Zhang M, Yuan H, Chen DD, Li K, Chen YL, Cao YM, Fu YF, Zhang J, Li D, Lu ZJ, Liu ZX, Luo JX. J Virol. 2019 Mar 21;93(7):e02278-18. doi: 10.1128/JVI.02278-18. PMID: 30700601; PMCID: PMC6430551