教师简介：
一、基本情况
姓 名：杨灵恩
性 别：女
政治面貌：群众
职 称：讲师
职 务：无
研究方向： 人兽共患传染病致病与免疫机制研究
联系电话：18597707015
电子邮箱：leyang@fafu.edu.cn
二、受教育经历
2011.09- 2015.07 河南农业大学，动物医学专业，学士学位；
2015.09- 2018.07 福建农林大学，预防兽医学专业，硕士学位；
2020.09- 2024.12 华中农业大学，预防兽医学专业，博士学位。
三、研究工作经历
2025.03至今 bat365在线官网平台，讲师
四、科研项目
1.国家自然科学基金联合基金项目,乳酰化修饰在流感病毒与宿主互作中的作用及其机制, 2026-01-01至2029-12-31, 257万元, 参与。
2.国家自然科学基金面上项目, CXCR3调节铁自噬在断奶应激仔猪肠上皮细胞氧化损伤中的作用机制研究, 2022-01-01至2025-12-31, 参与。
承担课程
讲授本科生《兽医免疫学》和《兽医微生物学与免疫学实验》课程。
六、科研成果
主要从事新型人兽共患病的发现以及重要人兽共患病的免疫与致病机制研究。近五年发表SCI论文10余篇，其中以第一作者和通讯作者在Journal of Neuroinflammation、Virologica Sinica、Frontiers in Microbiology、Virology、Infection, Genetics and Evolution发表论文5篇，授权专利1项。
代表性论文与著作
1.Ling’en Yang, Junyao Xiong, Yinguang Liu, Yixin Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao*, Jing Ye*. Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus.Journal of Neuroinflammation. 2024 Mar; 21:76.（“#”共同第一作者，“*”通讯作者，下同）
2.Ling’en Yang#, Zhihanb Zhao#, Guobin Hou, Chang Zhang, Jun Liu, Lin Xu, Wei Li, Zhizhou Tan, Changchun Tu*, Biao He*. Genomes and seroprevalence of severe fever with thrombocytopenia syndrome virus and Nairobi sheep disease virus in Haemaphysalis longicornis ticks and goats in Hubei, China.Virology. 2019 Mar; 529:234-245.
3.Ling’en Yang#, Jianmin Wu#, Tingsong Hu, Shaomin Qin, Bo Deng, Jinfeng Liu, Fuqiang Zhang*, Biao He*, Changchun Tu*. Genetic diversity of bat orthohepadnaviruses in China and a proposed new nomenclature.Infection, Genetics and Evolution. 2018 Sep; 63:135-143.
4.Ling’en Yang#, Quanxi Wang#, Lin Xu, Changchun Tu, Xiaohong Huang*, Biao He*. Detection and Characterization of a Novel Norovirus in Bats, China.Virologica Sinica. 2018 Feb;33(1):100-103.
5.Kaili Wang, Ting Ma, Minghui Ouyang, Xiao Fei*,Ling’en Yang* and Guijie Guo*. Roles of peptidylarginine deiminase (PAD) and protein citrullination in viral infections.Frontiers in Microbiology. 2026 Mar; 17:1792839.
6.Junyao Xiong,Ling'en Yang, Xiaowei Nan, Shuo Zhu, Mengxue Yan, Shengxian Xiang, Luping Zhang, Qi Li, Chengjie Yang, Xugang Wang, Ning Wei, Huanchun Chen, Youhui Si, Shengbo Cao, Jing Ye*. Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus.Journal of Extracellular Vesicles. 2025 Jan; 14(1): e70033.
7.Hongyang Liu, Yikai Chen, Hongyang Li,Ling’en Yang, Shili Yang, Xiaoying Luo, Song Wang, Ji-Long Chen, and Shihong Yan*. Pathogenicity, transmissibility, and immunogenicity of recombinant H9N2 avian influenza viruses based on representative viruses of Southeast China.Poultry Science. 2023 Jun;102(6):102625.
8.Bohan Zheng, Jiajun Sun, Haoran Luo,Ling’en Yang, Qi Li, Luping Zhang, Youhui Si, Shengbo Cao, Jing Ye*. Testosterone protects mice against zika virus infection and suppresses the inflammatory response in the brain.iScience. 2022 Oct 6;25(11):105300.
9.Junyao Xiong, Mengxue Yan, Shuo Zhu, Bohan Zheng, Ning Wei, Ling’en Yang, Youhui Si, Shengbo Cao, Jing Ye*. Increased Cleavage of Japanese Encephalitis Virus prM Protein Promotes Viral Replication but Attenuates Virulence.Microbiology Spectrum. 2022 Jun 29;10(3): e0141722.
10.Biao He, Wenjie Gong, Xiaomin Yan, Zihan Zhao,Ling’en Yang, Zhizhou Tan, et al. Viral metagenome-based precision surveillance of pig population at large scale reveals viromic signatures of sample types and influence of farming management on pig virome.mSystems, 2021, 6, e00420-21.
11.Lin Xu, Jianmin Wu, Qi Li, Yamei Wei, Zhizhou Tan, Jianqiu Cai, Huancheng Guo,Ling’en Yang, Xiaohong Huang, Jing Chen, Fuqiang Zhang*, Biao He*, Changchun Tu*. Seroprevalence, cross antigenicity and circulation sphere of bat-borne hantaviruses revealed by serological and antigenic analyses.PLoS Pathogens. 2019 Jan 22;15(1): e1007545.
12.Biao He, Xiaohong Huang, Fuqiang Zhang, Weilong Tan, Jelle Matthijnssens, Shaomin Qin, Lin Xu, Zihan Zhao,Ling'en Yang, Quanxi Wang, Tingsong Hu, Xiaolei Bao, Jianmin Wu*, Changchun Tu*. Group A Rotaviruses in Chinese Bats: Genetic Composition, Serology, and Evidence for Bat-to-Human Transmission and Reassortment.Journal of Virology. 2017 May 26;91(12): e02493-16.
13.李凤,黄攀锋,杨灵恩,郭桂杰*.DNA双链损伤修复蛋白RAD51在伪狂犬病病毒复制中的功能研究[J].中国兽医科学, 2025, 55(12):1574-1583.